The SAS proposals for participation in FP6 projects
are listed in blocks according to the FP6 priority theme structure

FP6 priority
1.1.1   Genomics and Biotechnology for Health
Title of the proposal

Adaptation of the heart on pressure overload during development of experimental hypertension. Remodeling.

Slovak Academy of Sciences, Institute for Heart Research
Dubravska cesta 9, 84233 Bratislava, Slovak Republic
Andrej DZURBA, PhD.
+421 2 54774405

Research subject for a potential FP6 project

The aim of the project is to obtain new data on the role of heart sarcolemmal transport enzyme systems for sodium, potassium and calcium ,expression of selected genes and intracellular connection of cardiomyocytes(connexin 43) in the structure and function of myocardium in defined stages of hypertension development using the model of spontaneously hypertensive rats.The main result of the project is the possible involvement of coordinated function of the sarcolemmal sodium and calcium pump and ATP-sensitive potassium channels in the intracellular signalling cascade in the course of myocardial remodeling.

Recent international cooperation of the research team

Cooperation between Dept. Pharmacol. Toxicol. Fac. Farmacy,Bratislava, Slovakia and Dept.Pharmacol., Fac. Med., Univ. Ottawa, Canada(Prof. BS Tuana, J. Kyselovic PhD., A. Dzurba PhD.)

Proposerīs relevant publications related to the research subject

1. Tuana BS, Dzurba A, Panagia V, Dhalla NS: Stimulation of heart sarcolemmal calcium pump by calmodulin. Biochem. Biophys. Res. Commun., 100, 1981, 1245-1250.
2. Dzurba A, Ziegelhoeffer A, Vrbjar N, Styk J, Slezak J: Estradiol modulates the sodium pump in the heart sarcolemma. Mol. Cell. Biochem., 176, 1997, 113-117.
3. Massart PE, Donckier J, Kyselovic J, Godfraind T, Heyndricks GR, Wibo M: Carvedilol and lacidipine prevent cardiac hypertrophy and endothelin-1 gene overexpression after aortic banding. Hypertension, 34, 1999, 1197-1201.