The SAS proposals for participation in FP6 projects
are listed in blocks according to the FP6 priority theme structure

FP6 priority
1.1.1   Genomics and Biotechnology for Health
Title of the proposal

Intracellular calcium release channels and cardiovascular diseases

Slovak Academy of Sciences, Institute of Molecular Physiology and Genetics
Vlarska 5, 833 34 Bratislava, Slovak Republic
Olga KRIZANOVA, Prof. Dr. Ph.D.
+421 2 54772211

Research subject for a potential FP6 project

Research subject is oriented on the modulation of intracellular calcium channels – IP3 receptor and ryanodine receptor – in cardiac tissue. These channels release calcium from the intracellular pools to cytoplasm. One part of our research is oriented on the modulation of these channels by factors that may potentially lead to the development of cardiovascular diseases (e.g. angiotensin II, adrenergic modulation, exposure to various stressors, myocardial infarction, ischemia, hypertension etc.). Intracellular calcium channels can be affected on the level of gene expression, protein translation and single channel activity. Thus, we will study the modulation of these channels at all three levels. Moreover, by blocking gene expression of these channels on primary cell cultures we can learn more about the physiological importance and metabolic regulation of these channels. Understanding of the mutual communication of ryanodine receptors and IP3 receptors with mitochondrial channels are also of the potential interest.

Recent international cooperation of the research team

Proposer´s relevant publications related to the research subject

1.Zacikova L., Ondrias K., Kvetnansky R., Krizanova O.: Identification of type 1 IP3 receptors in the rat kidney and their modulation by immobilization stress. Biochim Biophys Acta-Biomembranes, 1466; 16-22, 2000
2.Mojzisova A., Krizanova O., Zacikova L., Kominkova V., Ondrias K. Effect of nicotinic acid adenine dinucleotide phosphate on ryanodine calcium release channel in heart. Pflugers Arch. 441, 674-677, 2001
3.Kocan J., Lencesova L., Kiss A., Ondrias K., Kvetnansky R., Krizanova O. Distribution of neuronal and non-neuronal spliced variants of type 1 IP3 receptor in rat hypothalamus and brain stem. Neurochem Int. 41, 65-70, 2002