The SAS proposals for participation in FP6 projects
are listed in blocks according to the FP6 priority theme structure



FP6 priority
1.1.1   Genomics and Biotechnology for Health
1.1.2.1
Title of the proposal

Genetic aspects of type 1 diabetes mellitus in children and adolescents
Institute
Slovak Academy of Sciences, Institute of Molecular Biology
Dubravska cesta 21, 84251 Bratislava, Slovak Republic
imb.savba.sk
Contact
Name:
Viktor NAZAROV, PhD.
Phone:
+421 2 59307413
E-mail:
umbivikt@savba.sk


Research subject for a potential FP6 project

Clinical, immunological and genetic characterization of Slovak children and adolescents with type 1 diabetes – the relation between HLA class II and INS genes and the chosen group of antibodies (e.g. GAD65 Ab), the variability in the distribution of HLA class II and INS genes among children and adolescents with type 1 diabetes, possible prediction scheme of the type 1 diabetes.Association between type 1 diabetes and polymorphisms of the 5‘ end of the insulin gene, INS typing, study of possible imprinting.

Cloning, high level expression and structural biology of the highest risk for type 1 diabetes HLA class II dimer protein in Slovak population as a molecular basis for the role of HLA in diabetes development.

Association between the age at onset of type 1 diabetes and HLA and/or INS genes.


Recent international cooperation of the research team

Project EURODIAB TIGER
Project IDA
Project WHO DIAMOND


Proposer´s relevant publications related to the research subject

Nazarov, V. and Wolff, L. (1995). Novel integration sites at the distal 3\'-end of the c-myb locus in retrovirus-induced promonocytic leukemia. J. Virol. 69, 3885-3888.
Belli, B., Wolff, L., Nazarov, V., and Fan, H. (1995). Proviral activation of the c-myb proto-oncogene is detectable in preleukemic mice infected neonatally with Moloney murine leukemia virus but not in resulting end stage T lymphomas. J. Virol. 69, 5138-5141.
Koller, R., Krall, M., Mock, B., Bies, J., Nazarov, V., and Wolff, L. (1996). Mml1, a new common integration site in murine leukemia virus-induced promonocytic leukemias maps to mouse chromosome 10. Virology 224, 224-234.
Bies, J., Nazarov, V., and Wolff, L. (1999). Identification of protein instability determinants in the carboxy-terminal region of c-Myb removed as a result of retroviral integration in murine monocytic leukemias. J. Virol. 73, 2038-2044.
Schmidt, M., Nazarov, V., Stevens, L., Watson, R. and Wolff, L. (2000). Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis. Mol. Cell. Biol. 20,1970-81