The SAS proposals for participation in FP6 projects
are listed in blocks according to the FP6 priority theme structure

FP6 priority
1.1.1   Genomics and Biotechnology for Health
Title of the proposal

Improved cardiac diagnostics by non-invasive assessment and model-based interpretation of the cardiac electric field

Slovak Academy of Sciences, Institute of Measurement Science
Dubravska cesta 9, 842 19 Bratislava, Slovak Republic
Dr. Milan TYSLER
+421 2 5477 5950

Research subject for a potential FP6 project

The goal of the project is to improve diagnostic information content of the conventional electrocardiography by developing and applying new methods and instrumentation for accurate non-invasive \"electrocardiographic imaging\" and model-based examination of the heart state.Methods for topographic analysis of body surface potential maps (BSPM) will be proposed to assess the spatial distribution of the repolarisation that is in strong correlation with the risk of life threatening arrhythmias.
Model-based methods for non-invasive localisation of the sick parts of the heart will be proposed and analysed. As input, BSPM from sufficient number of leads and adequate geometrical information about the patient’s chest and heart will be used.
Their sensitivity and specificity will be studied by selection of appropriate classification criteria.Activation models helping to understand the activation process in the heart will be used in series of computer simulations. Analysis of conditions resulting in abnormal pattern of cardiac depolarisation and repolarisation in the BSPM will be performed.Advanced and cost-effective instrumentation for BSPM will be developed and offered to the community. Methods for BSPM and for model-based non-invasive localisation of arrhythmias will be implemented in the software.
Ability of proposed methods and instrumentation to help in pre-operational localisation of arrhythmogenic tissue and to detect patients at risk of arrhythmia will be clinically evaluated in cooperation with medical institutions.

Recent international cooperation of the research team

Department for Bioengineering, CRIP Research Institute for Technical Physics and Material Science, Hungarian Academy of Sciences, Budapest, Hungary;
Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia;
University of Veszprem, Veszprem, Hungary;

Proposerīs relevant publications related to the research subject

Cserjes Zs, Kozmann Gy, Sandor Gy, Sztahmary V, Svehlikova J, Tysler M: Influence of heart position on ventricular characteristic event detection by linear predictive algorithm. In: Electrocardiology \'98, Proceedings of the XXVth ICE, World Scientific,1999, 55-58.
Tinova M, Tysler M, Turzova M: Localization of early activation sites using measured BSPM data. In: Electrocardiology \'99: Proceedings of the XXVIth ICE, Russian Academy of Sciences, 2000, 114-120.
Rosik V, Tysler M, Jurko S, Raso R, Turzova M: Portable system for high resolution ECG mapping. Measurement Science Review (
), 1, 2001, 27-30.Tysler M, Turzova M, Szathmary V: Projection of local changes of ventricular action potential to surface distribution of activation-recovery intervals. Biomedizinische Technik, Band 46, Erganzungsband 2, 2001, 60-62